《核磁共振的物理學和數(shù)學(英文)》是一部英文版的物理學專著,中文書名可譯為《核磁共振的物理學和數(shù)學》,《核磁共振的物理學和數(shù)學(英文)》的作者有兩位,一位是理查德·安索格(Richard Ansorge),他是劍橋卡文迪什實驗室(Cavendish Laboratory Cambridge)的高級講師,也是劍橋菲茨威廉學院(Fitzwilliam College Cambridge)的研究員和大學導師。他在實驗高能物理方面擁有豐富的經(jīng)驗,最近,他與劍橋生物醫(yī)學校區(qū)的研究小組進行了多個領(lǐng)域的合作,包括改進MRI和PET等3D醫(yī)學成像方法。他出版了100多本有關(guān)這些領(lǐng)域的著作。他于1964年為EDSAC2編寫了他的第1個計算機程序,此后一直從事編碼工作,最近,他使用GPU開發(fā)了用于三維醫(yī)學圖像配準的代碼,其功能可能比EDSAC強10(10)倍。他擁有豐富的本科教學經(jīng)驗,還發(fā)表了幾次關(guān)于醫(yī)學成像的廣受歡迎的演講。
Clinical medical imaging has come a long way since the discovery of X-rays by Wilhelm Roentgen in 1895. Conventional planar X-ray imaging is still very much used, albeit often using more sensitive solid state digital detectors rather than film. X-rays are also used in CT scanners to provide exquisite 3D views of anatomy, particularly bone structure. Positron emission tomography (PET) is a much more recent tool, capable of 3D imaging of metabolic process, it has applications in oncology and basic research. Ultrasound is also a relatively recent tool, it is relatively inexpensive, quick and easy to use, it has many applications, including obstetrics-where it is safe to use because it does not need ionising radiation. Finally, there is magnetic resonance imaging (MRI). Introduced in the mid 1980s at roughly a similar time to PET and CT, it uses dramatically different physical principles to the other modalities and has also turned out to be far more versatile in its range of applications than any other modality.
MR1 uses magnetic fields not ionising radiation and hence is just as safe to use as ultrasound, however the necessary equipment is certainly more complicated and expensive. The physical principles involved are also very different, they are subtle, complex and a wonderful example of physics in action.
Richard Ansorge,a retired senior lecturer at the Cavendish Laboratory Cambridge and a former fellow and tutor of Fitzwilliam College Cambridge. He has extensive experience of experimental high energy physics, including significant contributions to the CERN UA5 experiment on the proton-antiproton collider in the 1980s. More recently he has collaborated with research groups on the Cambridge Biomedical campus in several areas including improving 3D medical imaging methods including MRI and PET. He is author of more than 100 scientific publications in these fields. He is particularly interested in applying computers for processing data from complex instrumentation. This has applications which are equally relevant in both high energy physics and medical imaging. He wrote his first computer program in 1964 for EDSAC2 and has been coding ever since. Much more recently he has developed code for 3D medical image registration using GPUs which are probably 10(10) times more powerful than EDSAC.
Martin Graves,a Consultant Clinical Scientist and lead of the Cambridge University Hospitals MR Physics group. He also holds an Affiliated Lecturer position with the University of Cambridge Clinical School. He is a Fellow of the Institute of Physics and Engineering in Medicine (IPEM), a Fellow of the Higher Education Academy (HEA), member of the Institute of Engineering and Technology (IET) and is an Honorary Member of the Royal College of Radiologists (RCR), He has served on various national and international committees including the British Institute of Radiology (BIR), the International Society of Magnetic Resonance in Medicine (ISMRM) and the European Society of Magnetic Resonance in Medicine and Biology (ESMRMB). He is a member of the editorial board of European Radiology.
Preface
Acknowledgements
Introduction
Symbols and Acronyms
Author biographies
1 The basics
1.1 A brief history of MRI
1.1.1 Spin and magnetic moments
1.1.2 NMR
1.1.3 MRI
1.1.4 Superconductivity
1.2 Proton spin
1.2.1 Precession
1.3 The Bloch equations
1.4 Signal generation
1.4.1 Reversing T2* effects-spin-echo
1.4.2 T1 Sensitivity-inversion recovery
1.4.3 Image contrast
1.5 Spatial encoding using magnetic field gradients
1.5.1 Lauterbur's tomographic method
1.5.2 Gradients and k-space
1.6 Spatialimage formation
1.6.1 Pulse sequences
1.6.2 Slice select
1.6.3 Phase encode
1.6.4 Frequency encode
1.6.5 Rewind and repeat
1.7 Conclusion
References
2 Magnetic field generation
2.1 Designing the main magnet
2.1.1 Magnetic field of circular coil
2.1.2 Combining coils
2.1.3 Off-axis fields
2.2 Designing gradient coils
2.2.1 Axial gradients
2.2.2 Transverse gradients
2.3 Practical issues
2.3.1 Main magnet
2.3.2 Keeping cool
2.3.3 Gradients
2.3.4 Pre-emphasis
2.3.5 Shielding and shimming
2.3.6 Safety
References
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3 Radio frequency transmission and reception
4 Pulse sequences and images
5 Applications
6 Conclusion
Appendices
編輯手記